Doxycycline hydrochloride
Broad Antibacterial Spectrum: This compound demonstrates efficacy against both Gram-positive and Gram-negative bacteria, including strains resistant to tetracycline antibiotics.
High Potency: Exhibiting approximately tenfold greater antibacterial activity compared to tetracycline, it delivers enhanced therapeutic effectiveness.
Versatile Treatment Applications: It is employed in managing diverse infections such as respiratory and urinary tract infections, typhoid fever, and mycoplasma pneumonia.
Favorable Solubility Profile: With high water solubility, the compound ensures optimal absorption characteristics and bioavailability in therapeutic applications.
Doxycycline hydrochloride presents as a light blue or yellow crystalline powder. It is odorless with a characteristic bitter taste and exhibits hygroscopic nature. The compound demonstrates high solubility in water and methanol, while showing limited solubility in ethanol and acetone.
This broad-spectrum antibacterial agent exhibits activity against both Gram-positive cocci and Gram-negative bacilli. Its antibacterial potency is approximately ten times greater than that of tetracycline, maintaining efficacy against tetracycline-resistant strains. Clinical applications include treatment of respiratory tract infections, chronic bronchitis, pneumonia, urinary tract infections, as well as macules, typhoid fever, and mycoplasma pneumonia (CAS Registry Number: 24390-14-5).
Parameters
Melting point | 195-201℃ |
Fp | 87℃ |
storage temp. | Inert atmosphere,2-8°C |
solubility | H2O: 50 mg/mL, clear, yellow-green |
form | powder |
color | yellow |
biological source | synthetic |
Water Solubility | Soluble in water. |
BCS Class | 1 |
InChIKey | RUYHIJHUVHIMIR-PGTYNCOMNA-N |
SMILES | O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])[C@H]([C@]1([H])[C@H](C3C=CC=C(O)C=3C(=O)C1=C2O)C)O)=O.Cl |&1:1,9,13,15,16,18,r| |
CAS DataBase Reference | 10592-13-9(CAS DataBase Reference) |
Safety Information
Hazard Codes | Xn,Xi |
Risk Statements | 22-36/37/38 |
Safety Statements | 26-36/37 |
RIDADR | NA 1993 / PGIII |
WGK Germany | 3 |
F | 8 |
HS Code | 29413000 |
