Dexamethasone
Anti-inflammatory Properties: Dexamethasone exerts potent anti-inflammatory effects by suppressing inflammatory mediators, effectively alleviating symptoms associated with various inflammatory conditions.
Combination Therapy: It is frequently administered in conjunction with other therapeutic agents, demonstrating synergistic effects that enhance treatment efficacy and provide comprehensive clinical management.
Versatility in Treatment: Owing to its anti-toxic and anti-allergic actions, dexamethasone is employed in diverse therapeutic areas including allergic reactions, autoimmune diseases, and shock management.
Symptom Management: Although not curative, dexamethasone effectively controls pathological processes through immunomodulation and inflammatory response suppression, making it invaluable for symptomatic management across multiple disease states.
Dexamethasone is a clinically significant corticosteroid medication frequently employed in combination therapy regimens to optimize treatment efficacy. It demonstrates potent anti-inflammatory, anti-toxic, and anti-allergic properties through its immunosuppressive effects on various inflammatory mediators.
While highly effective for symptomatic control, dexamethasone functions as a suppressive agent rather than a curative treatment, primarily alleviating pathological manifestations without addressing underlying disease causes. Its clinical application requires co-administration with other therapeutic agents to ensure comprehensive disease management. This combination approach enhances overall treatment outcomes while maintaining appropriate control over inflammatory processes across various medical conditions.
Parameters
Melting point | 262-264 °C (lit.) |
alpha | 75 º (c=1, dioxane) |
Boiling point | 568.2±50.0 °C(Predicted) |
density | 1.1283 (estimate) |
refractive index | 76 ° (C=1, Dioxane) |
Fp | 9℃ |
storage temp. | 2-8°C |
solubility | ethanol: 1 mg/mL |
form | |
pka | 12.13±0.70(Predicted) |
color | off-white |
biological source | synthetic (organic) |
Water Solubility | 10 mg/100 mL (25 ºC) |
Sensitive | Light Sensitive |
Merck | 142943 |
BRN | 2066651 |
BCS Class | 1 (CLogP), 3 (LogP) |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, acid anhydrides, acid chlorides. May be light sensitive. |
InChIKey | UREBDLICKHMUKA-CXSFZGCWSA-N |
CAS DataBase Reference | 50-02-2(CAS DataBase Reference) |
NIST Chemistry Reference | Prednisolone, 9alpha-fluoro-16alpha-methyl-(50-02-2) |
EPA Substance Registry System | Dexamethasone (50-02-2) |
Safety Information
Hazard Codes | Xi,Xn,T,F |
Risk Statements | 43-40-36/37/38-20/21/22-42/43-39/23/24/25-23/24/25-11 |
Safety Statements | 36/37-45-36-26-22-16 |
RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 2 |
RTECS | TU3980000 |
TSCA | Yes |
HS Code | 29372210 |
Hazardous Substances Data | 50-02-2(Hazardous Substances Data) |
Toxicity | LD50 oral in rat: > 3gm/kg |
