Ibuprofen
Therapeutic Efficacy in Pain and Inflammation Management: Ibuprofen functions as a widely utilized non-steroidal anti-inflammatory drug, demonstrating potent antipyretic, analgesic, and anti-inflammatory properties.
Favorable Safety Profile: This medication provides effective pain management with enhanced tolerability relative to other NSAIDs, establishing its preference in clinical practice.
Versatile Clinical Applications: Ibuprofen maintains global recognition as a primary over-the-counter therapeutic agent for conditions including arthritic disorders, musculoskeletal discomfort, and cephalalgia.
Stability and Storage Characteristics: The compound preserves its chemical integrity and therapeutic efficacy when stored under recommended cool, dry conditions, ensuring reliable pharmaceutical performance.
Ibuprofen, chemically designated as isobutylphenyl propionic acid, is classified within the non-steroidal anti-inflammatory drug (NSAID) category. This therapeutic agent exhibits well-documented anti-inflammatory, analgesic, and antipyretic efficacy while demonstrating a favorable profile of infrequent adverse reactions. Its extensive global acceptance has established it as one of the most commercially successful over-the-counter medications worldwide. Together with aspirin and paracetamol, ibuprofen constitutes one of the three fundamental antipyretic-analgesic pharmaceutical products.
Melting point | 77-78 °C |
Boiling point | 157 °C (4 mmHg) |
alpha | [α]D20 -1～+1°(c=1,C2H5OH) |
density | 1.0364 (rough estimate) |
refractive index | 1.5500 (estimate) |
Fp | 9℃ |
storage temp. | 2-8°C |
solubility | Practically insoluble in water, freely soluble in acetone, in methanol and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides and carbonates. |
pka | pKa 4.45± 0.04(H2O,t = 25±0.5,I=0.15(KCl))(Approximate) |
form | Crystalline Powder |
color | white to off-white |
biological source | synthetic (organic) |
Water Solubility | insoluble |
Merck | 144881 |
BCS Class | 2 |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
InChIKey | HEFNNWSXXWATRW-UHFFFAOYSA-N |
LogP | 3.97 |
CAS DataBase Reference | 15687-27-1(CAS DataBase Reference) |
NIST Chemistry Reference | Ibuprofen(15687-27-1) |
EPA Substance Registry System | Benzeneacetic acid, .alpha.-methyl-4-(2-methylpropyl)- (15687-27-1) |
Safety Information | |
Hazard Codes | Xn |
Risk Statements | 22-63-51/53-39/23/24/25-23/24/25-11 |
Safety Statements | 36-61-36/37-45-16-7 |
HS Code | 29163920 |
Hazardous Substances Data | 15687-27-1(Hazardous Substances Data) |
Toxicity | LD50 in male mice, rats (mg/kg): 495, 626 i.p.; 1255, 1050 orally (Orzalesi) |
Within the Chinese pharmaceutical market, this drug is predominantly employed for pain management and rheumatological conditions, whereas its application in treating common colds and fever reduction remains comparatively limited. This utilization pattern shows substantial disparity with the more extensive use of paracetamol and aspirin in these therapeutic areas.
