Fluconazole CAS：86386-73-4

Broad Antifungal Spectrum

Fluconazole delivers potent antifungal activity covering both invasive systemic mycosis and superficial fungal ailments, supporting extensive clinical treatment scenarios.

Highly Selective Enzyme Blocking

This triazole agent selectively suppresses fungal cytochrome P450-linked lanosterol 14α-demethylase. Suppression of this key catalyst disrupts ergosterol biosynthesis, a sterol indispensable for maintaining fungal cell membrane structural integrity.

Disruption of Fungal Sterol Production

By restraining core catalytic steps in the fungal sterol metabolic pathway, fluconazole undermines cell membrane stability and suppresses fungal viability effectively.

Proven Clinical Performance

Thanks to its targeted pharmacological action and stable therapeutic efficacy, fluconazole has evolved into a mainstream first-line drug for managing diverse fungal infectious disorders.

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Product Details

As a triazole antifungal active substance first researched and manufactured by Pfizer, fluconazole exerts powerful antimycotic effects on various invasive fungal diseases. Its therapeutic mechanism lies in the specific suppression of fungus-specific cytochrome P450-related enzymes, predominantly lanosterol 14-α-demethylase. Blocking this enzyme hinders the production of ergosterol, a vital lipid that maintains the structural completeness of fungal cell membranes.

Fluconazole CAS：86386-73-4

This active ingredient can additionally suppress core enzymatic reactions involved in fungal sterol metabolism to strengthen its antimycotic potency. Owing to its precise molecular mode of action and stable treatment outcomes, fluconazole is widely accepted as a standard clinical drug to treat various fungal disorders.

Parameters

Melting point	138-140°C
Boiling point	579.8±60.0 °C(Predicted)
density	1.05
Fp	9℃
storage temp.	2-8°C
solubility	DMSO: 5 mg/mL
form	solid
pka	pKa 1.76±0.1(H2O t=24 I=0.1(NaCl)) (Uncertain)
color	White to Off-White
Water Solubility	1g/L(temperature not stated)
Merck	144122
BCS Class	1,3
InChI	InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
InChIKey	RFHAOTPXVQNOHP-UHFFFAOYSA-N
SMILES	C1(C=CC(F)=CC=1F)C(O)(CN1N=CN=C1)CN1N=CN=C1
CAS DataBase Reference	86386-73-4(CAS DataBase Reference)
Safety Information Hazard Codes	Xn,Xi,T,F
Risk Statements	22-36/37/38-20/21/22-39/23/24/25-23/24/25-11
Safety Statements	26-36-36/37/39-24/25-45-36/37-16-7
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS	XZ4810000
HS Code	29336990
Hazardous Substances Data	86386-73-4(Hazardous Substances Data)