Fluconazole
Broad-Spectrum Antifungal Activity: Fluconazole demonstrates comprehensive antifungal coverage against systemic and superficial fungal infections, supporting diverse therapeutic applications.
Selective Enzyme Inhibition: The compound specifically targets fungal cytochrome P-450-dependent lanosterol 14α-demethylase, disrupting ergosterol synthesis essential for fungal membrane integrity.
Ergosterol Biosynthesis Interference: By inhibiting key steps in fungal sterol synthesis, Fluconazole effectively compromises membrane stability and fungal viability.
Clinical Reliability: Recognized for its targeted action and consistent efficacy, Fluconazole has become an established therapeutic choice for fungal infection management.
Fluconazole, a triazole-class antifungal agent originally developed by Pfizer, exhibits broad-spectrum activity against systemic fungal infections. It functions through selective inhibition of fungal cytochrome P-450-dependent enzymes, particularly lanosterol 14-α-demethylase, which disrupts ergosterol biosynthesis essential for fungal cell membrane integrity.
The compound further demonstrates specific inhibition of key enzymatic processes in fungal sterol synthesis, enhancing its antifungal efficacy. Recognized for its targeted mechanism and reliable therapeutic performance, fluconazole has become a clinically established option for managing diverse fungal pathologies.
Parameters
Melting point | 138-140°C |
Boiling point | 579.8±60.0 °C(Predicted) |
density | 1.05 |
Fp | 9℃ |
storage temp. | 2-8°C |
solubility | DMSO: 5 mg/mL |
form | solid |
pka | pKa 1.76±0.1(H2O t=24 I=0.1(NaCl)) (Uncertain) |
color | White to Off-White |
Water Solubility | 1g/L(temperature not stated) |
Merck | 144122 |
BCS Class | 1,3 |
InChI | InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 |
InChIKey | RFHAOTPXVQNOHP-UHFFFAOYSA-N |
SMILES | C1(C=CC(F)=CC=1F)C(O)(CN1N=CN=C1)CN1N=CN=C1 |
CAS DataBase Reference | 86386-73-4(CAS DataBase Reference) |
Safety Information Hazard Codes |
Xn,Xi,T,F |
Risk Statements | 22-36/37/38-20/21/22-39/23/24/25-23/24/25-11 |
Safety Statements | 26-36-36/37/39-24/25-45-36/37-16-7 |
RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 3 |
RTECS | XZ4810000 |
HS Code | 29336990 |
Hazardous Substances Data | 86386-73-4(Hazardous Substances Data) |
