Ethyl acetate
Solvent Properties: Ethyl acetate demonstrates miscibility with multiple organic solvents including ethanol, acetone, and benzene, supporting its application across diverse formulation systems.
Aroma Characteristics: The compound possesses a characteristic ester-like aroma detectable at minimal concentrations, enabling its implementation in fragrance compositions and flavor formulations.
Volatility Profile: With a boiling point of 76.5°C, the solvent facilitates processes requiring rapid evaporation rates and efficient recovery.
Stability and Handling Considerations: While maintaining chemical stability under standard conditions, the ester exhibits significant flammability requiring appropriate safety measures during storage and processing.
Ethyl acetate represents a fundamental ester compound in chemical education and industrial applications, serving as a frequently encountered example in organic chemistry curricula. Structurally derived from acetic acid through substitution of the carboxyl hydrogen with an ethanol-derived ethyl group, this compound presents as a colorless, mobile liquid under standard conditions. Characterized by a distinctive fruity aroma and a boiling point of 77°C, its combination of accessible synthesis, favorable volatility, and pleasant olfactory properties establishes its utility across pharmaceutical, food, and chemical manufacturing sectors.
Ethyl acetate Chemical Properties
Melting point | −84 °C(lit.) |
Boiling point | 76.5-77.5 °C(lit.) |
density | 0.902 g/mL at 25 °C(lit.) |
vapor density | 3 (20 °C, vs air) |
vapor pressure | 73 mm Hg ( 20 °C) |
refractive index | n20/D 1.3720(lit.) |
FEMA | 2414 | ETHYL ACETATE |
Fp | 26 °F |
storage temp. | Store at +2°C to +25°C. |
solubility | Miscible with ethanol, acetone, diethyl ether and benzene. |
pka | 16-18(at 25℃) |
form | Liquid |
Specific Gravity | 0.902 (20/20℃) |
color | APHA: ≤10 |
Odor | Pleasant fruity odor detectable at 7 to 50 ppm (mean = 18 ppm) |
Relative polarity | 0.228 |
explosive limit | 2.2-11.5%, 38°F |
Odor Threshold | 0.87ppm |
Odor Type | ethereal |
biological source | synthetic |
Water Solubility | 80 g/L (20 ºC) |
λmax | λ: 256 nm Amax: ≤1.00 |
JECFA Number | 27 |
Merck | 14,3757 |
BRN | 506104 |
Henry's Law Constant | 0.39 at 5.00 °C, 0.58 at 10.00 °C, 0.85 at 15.00 °C, 1.17 at 20.00 °C, 1.58 at 25.00 °C (column stripping-UV, Kutsuna et al., 2005) |
Exposure limits | TLV-TWA 400 ppm (～1400 mg/m3) (ACGIH, MSHA, and OSHA); IDLH 10,000 ppm (NIOSH). |
Dielectric constant | 23.0（Ambient） |
Stability: | Stable. Incompatible with various plastics, strong oxidizing agents. Highly flammable. Vapour/air mixtures explosive. May be moisture sensitive. |
InChIKey | XEKOWRVHYACXOJ-UHFFFAOYSA-N |
LogP | 0.68-0.73 at 20-25℃ |
Surface tension | 23.93mN/m at 293.15K |
CAS DataBase Reference | 141-78-6(CAS DataBase Reference) |
NIST Chemistry Reference | Ethyl acetate(141-78-6) |
EPA Substance Registry System | Ethyl acetate (141-78-6) |
Safety Information
Hazard Codes | F,Xi,Xn,T |
Risk Statements | 11-36-66-67-20/21/22-10-39/23/24/25-23/24/25-68/20/21/22 |
Safety Statements | 16-26-33-36/37-45-7-25 |
RIDADR | UN 1173 3/PG 2 |
OEB | A |
OEL | TWA: 400 ppm (1400 mg/m3) |
WGK Germany | 1 |
RTECS | AH5425000 |
F | 1 |
Autoignition Temperature | 427 °C |
TSCA | Yes |
HS Code | 2915 31 00 |
HazardClass | 3 |
PackingGroup | II |
Hazardous Substances Data | 141-78-6(Hazardous Substances Data) |
Toxicity | LD50 orally in rats: 11.3 ml/kg (Smyth) |
IDLA | 2,000 ppm [10% LEL] |
