Gentamicin sulfate
Broad-Spectrum Antimicrobial Activity: Demonstrates efficacy against Gram-negative bacteria, including Escherichia coli, Shigella species, and Pseudomonas aeruginosa.
Versatile Therapeutic Applications: Employed in the management of systemic, localized, ophthalmic, and intestinal infections, as well as preoperative prophylaxis for colorectal surgical interventions.
Synergistic Combination Therapy: Enhances postoperative infection prevention through concurrent administration with metronidazole or clindamycin.
Stability and Efficacy Profile: Maintains chemical integrity in aqueous solutions at 37°C for periods of up to 5 days, ensuring consistent and dependable therapeutic performance.
Gentamicin sulfate represents an aminoglycoside-class bactericidal antibiotic comprising amino sugar and ligand molecular structures. As the sulfate derivative of gentamicin, this compound exhibits an antimicrobial spectrum analogous to kanamycin. The antibiotic is primarily utilized for treating systemic and localized infections caused by Gram-negative pathogens such as Escherichia coli, Shigella dysenteriae, Klebsiella pneumoniae, Proteus species, and Pseudomonas aeruginosa. In ophthalmological practice, it is indicated for conditions including conjunctivitis and keratitis.
Parameters
Melting point | 218-237°C |
alpha | D25 +102° |
density | 1.000 g/cm3 |
storage temp. | 2-8°C |
solubility | H2O: 50 mg/mL As stock solution, store at −20°C. Stable at 37°C for 5 days. |
form | |
color | colorless to light yellow |
Odor | odorless |
PH | 4.0-5.5 (0.1g/mL in H2O) |
optical activity | [α]20/D +110±8°, c = 1% in H2O |
biological source | Micromonospora purpurea |
Water Solubility | Soluble in water |
Merck | 134403 |
InChIKey | RDEIXVOBVLKYNT-HDZPSJEVSA-N |
CAS DataBase Reference | 1405-41-0(CAS DataBase Reference) |
EPA Substance Registry System | Gentamicin sulfate (1405-41-0) |
Safety Information | |
Hazard Codes | Xn |
Risk Statements | 42/43 |
Safety Statements | 23-36/37-45-22-24/25 |
WGK Germany | 2 |
RTECS | LY2625000 |
F | 3 |
HS Code | 29419010 |
Toxicity | LD50 in mice (mg base/kg): 430 i.p.; 485 s.c.; 75 i.v.; >9050 orally (Black) |
For intestinal infections or preoperative bowel preparation in colorectal surgical procedures, the antibiotic may be administered via the oral route. Furthermore, when used in combination with metronidazole or clindamycin, it demonstrates efficacy in reducing postoperative infection incidence following colon surgery.
