Idebenone
Solubility and Stability Profile: This compound demonstrates a lipophilic nature, exhibiting high solubility in DMSO and various organic solvents while remaining insoluble in aqueous systems. It maintains chemical integrity for extended periods (up to one year) when stored under recommended low-temperature conditions. Physicochemical Characteristics:
Idebenone presents as an orange-colored crystalline solid with a relatively low melting point. It is readily soluble in diverse organic media but shows negligible dissolution in water.
Therapeutic and Cosmetic Applications: Primarily employed in pharmaceutical formulations for its antioxidant activity and mitochondrial function modulation, with emerging applications in neurodegenerative disease management. Additionally utilized in cosmetic products for skin protection and rejuvenation.
Safety and Handling Requirements: Classified as a category Xi irritant, necessitating proper handling protocols to prevent dermal and ocular exposure. Implementation of appropriate personal protective equipment is mandatory during research and manufacturing processes.
Idebenone presents as a yellow crystalline or powdered material without detectable odor. The compound demonstrates negligible aqueous solubility while exhibiting ready dissolution in chloroform, methanol, and anhydrous ethanol. It shows solubility in ethyl acetate but remains insoluble in n-hexane.
Melting point | 52-550C |
Boiling point | 497.3±45.0 °C(Predicted) |
density | 1.08±0.1 g/cm3(Predicted) |
storage temp. | room temp |
solubility | Soluble in DMSO (up to 25 mg/ml). |
form | Solid |
pka | 15.20±0.10(Predicted) |
color | Orange |
Merck | 14,4888 |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
InChI | InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3 |
InChIKey | JGPMMRGNQUBGND-UHFFFAOYSA-N |
SMILES | C1(=O)C(OC)=C(OC)C(=O)C(C)=C1CCCCCCCCCCO |
LogP | 3.490 (est) |
CAS DataBase Reference | 58186-27-9(CAS DataBase Reference) |
Safety Information
Hazard Codes | Xi |
WGK Germany | 3 |
RTECS | GU5290000 |
HS Code | 2933399990 |
