Squalane, CAS#111-01-3
Appearance: It is a colorless, transparent oily liquid, odorless or with very faint characteristic odor, featuring low viscosity and excellent spreadability.
Solubility: Insoluble in water and glycerin; miscible with ether, chloroform, hydrocarbon oils and most cosmetic lipids.
Stability & pH Performance: Neutral substance, pH is around 6.0–7.0. It has outstanding oxidation resistance, not easy to rancidify compared with unsaturated squalene; stable under normal storage conditions.
Basic Function Features: It is saturated branched alkane hydrogenated from squalene. It has excellent emollient, moisturizing, skin barrier repairing and lubricating properties, with good skin affinity and low irritation.
Squalane, characterized by the molecular formula C₃₀H₆₂, presents as colorless transparent oily liquid. It cannot mix with aqueous phase raw materials but is freely miscible with various plant oils, mineral oils and lipophilic cosmetic ingredients. It is saturated hydrocarbon, so it avoids autoxidation and rancidity issues of squalene. The substance is highly compatible with human sebum, easy to spread on skin without heavy greasy feeling. It is widely used as premium emollient in high-end skincare and hair care formulations.
| Chemical Properties | Parameter |
|---|---|
| CAS No. | 111-01-3 |
| Molecular Formula | C₃₀H₆₂ |
| Molecular Weight | 422.81 g/mol |
| Appearance | Colorless transparent oily liquid |
| Odor | Odorless or faint characteristic odor |
| Refractive Index | 1.450–1.453 (20℃) |
| Density | 0.810–0.815 g/cm³ (20℃) |
| Boiling Point | 350 °C |
| Flash Point | 218 °C |
| pH | 6.0–7.0 |
| Solubility | Insoluble in water, glycerin; miscible with ether, chloroform, hydrocarbon oils |
| Storage Temp | Store at 10–30 ℃, sealed, protected from light |
| Stability | Good oxidation stability; incompatible with strong oxidizing agents |
| Acid Value | ≤0.1 mg KOH/g |
| Saponification Value | ≤0.5 mg KOH/g |
| InChIKey | ZDXPYRJPNDTMRX-UHFFFAOYSA-N |
| NIST Chemistry Reference | Squalane (111-01-3) |
| EPA Substance Registry System | Squalane |
| Safety Information | Details |
|---|---|
| GHS Classification | Not classified as hazardous |
| Hazard Statements | Not applicable |
| Precautionary Statements | P264, P280 |
| Risk Statements | None |
| Safety Statements | S24/25 |
| WGK Germany | 1 |
| RTECS | Not available |
| Grade | Cosmetic Grade |
| TSCA | Yes |
| HS Code | 29011000 |
| Hazard Description | Low irritation, low acute toxicity; generally safe for topical use |
| Handling Advice | Avoid splashing into eyes; wear protective gloves when handling; prevent slipping from spillage |
| Storage Requirement | Keep tightly sealed, cool, dry and away from light; separate from strong oxidants |
This compound is widely used in facial creams, serums, facial oils, lotions, eye care products, lip care products and hair care oil formulations. It softens skin, locks moisture, strengthens skin barrier and reduces transepidermal water loss. It helps relieve dry and rough skin, and can reduce the irritation of other active ingredients. It is also used as lubricant in pharmaceutical topical preparations and auxiliary oil phase material in some high-end makeup products. Due to its mildness and excellent skin affinity, it is one of the most popular emollient oils in the cosmetic industry.
