L-Carnosine
Versatile Biological Activity: L-Carnosine is naturally present in multiple tissues including brain, muscle, and kidney, where it performs diverse physiological functions.
Metal Chelation: It serves as an effective chelating agent, binding to metal ions such as copper, zinc, and nickel to help maintain metal ion homeostasis.
Health Benefits: This dipeptide contributes to various aspects of human health, with particular benefits for muscular and neurological functions.
Antioxidant Properties: Recognized for its ability to mitigate oxidative stress, L-Carnosine supports overall cellular protection and wellness maintenance.
L-Carnosine (β-alanyl-L-histidine, CAS 305-84-0) is an endogenous dipeptide composed of β-alanine and L-histidine, naturally occurring in both rat tissues (including olfactory bulb, skeletal muscle, brain, kidney, and spleen) and human skeletal muscle. It demonstrates broad biological activity, functioning as an effective metal chelator that forms stable complexes with copper, cobalt, nickel, cadmium, and zinc ions.
The compound finds versatile applications across multiple sectors: in pharmaceutical research for neuroprotective and cardiovascular studies; in dietary supplements as an antioxidant and anti-aging ingredient; in food technology as a functional additive; in cosmetic formulations for skin aging intervention; and in scientific investigations related to its physiological mechanisms.
Safety Information
Melting point | 253 °C (dec.) (lit.) |
alpha | 20.9 º (c=1.5, H2O) |
Boiling point | 367.84°C (rough estimate) |
density | 1.2673 (rough estimate) |
vapor pressure | 0Pa at 25℃ |
refractive index | 21 ° (C=2, H2O) |
storage temp. | -20°C |
solubility | DMSO (Very Slightly), Water (Slightly) |
pka | 2.62(at 25℃) |
form | crystalline |
color | White |
Odor | at 100.00?%. odorless |
Optical Rotation | +24.120 |
Water Solubility | almost transparency |
Merck | 14,1850 |
BRN | 87671 |
Stability: | Stable, but may be heat sensitive - store cold. Incompatible with strong oxidizing agents. |
InChIKey | CQOVPNPJLQNMDC-ZETCQYMHSA-N |
LogP | -3.8 at 22℃ |
CAS DataBase Reference | 305-84-0(CAS DataBase Reference) |
EPA Substance Registry System | L-Histidine, .beta.-alanyl- (305-84-0) |
Safety Information
Hazard Codes | Xn |
Risk Statements | 20/21/22-36/37/38 |
Safety Statements | 24/25-36-26 |
WGK Germany | 2 |
RTECS | MS3080000 |
F | 3-10 |
TSCA | Yes |
HS Code | 29332900 |
Toxicity | LD50 oral in mouse: > 14930mg/kg |
