Acetylsalicylic acid
Analgesic and Anti-inflammatory Properties: Aspirin demonstrates well-established non-steroidal anti-inflammatory activity, with extensive clinical application for its analgesic and anti-inflammatory effects.
Antithrombotic Mechanism: The drug inhibits platelet aggregation through irreversible cyclooxygenase blockade, delivering effective antithrombotic protection against clot formation.
Cardiovascular Protection: Aspirin therapy significantly reduces mortality risk associated with acute myocardial infarction and cerebrovascular accidents, supporting cardiovascular health maintenance.
Chemopreventive Potential: Emerging research indicates aspirin may attenuate colorectal cancer incidence, thereby expanding its therapeutic value beyond conventional applications.
Aspirin, chemically identified as acetylsalicylic acid, represents a nonsteroidal anti-inflammatory drug (NSAID) originally developed for its anti-inflammatory and analgesic characteristics. Subsequent research revealed its capacity to inhibit platelet aggregation through irreversible cyclooxygenase inhibition, thereby generating antithrombotic effects. As scientific investigation advanced, multiple additional therapeutic applications have been established. These include demonstrated efficacy in reducing mortality rates in myocardial infarction and stroke, along with evidence supporting its role in diminishing colorectal cancer incidence, collectively expanding its clinical utility beyond initial indications.
Melting point | 134-136 °C (lit.) |
Boiling point | 272.96°C (rough estimate) |
density | 1.35 |
refractive index | 1.4500 (estimate) |
Fp | 250 °C |
storage temp. | 2-8°C |
solubility | H2O: 10 mg/mL at 37 °C |
form | crystalline |
color | white |
pka | 3.5(at 25℃) |
biological source | synthetic |
Water Solubility | 3.3 g/L (20 ºC) |
ε(extinction coefficient) | 190 at 298nm in aqueous base at 1mM |
409 at 231nm in aqueous base at 1mM | |
466 at 230nm in aqueous acid at 1mM | |
68 at 278nm in aqueous acid at 1mM | |
Merck | 14851 |
BRN | 779271 |
Exposure limits | ACGIH: TWA 5 mg/m3 |
NIOSH: TWA 5 mg/m3 | |
BCS Class | 3 |
Stability: | Stable. Keep dry. Incompatible with strong oxidizing agents, strong bases, strong acids, various other compounds such as iodides, iron salts, quinine salts, etc. |
InChIKey | BSYNRYMUTXBXSQ-UHFFFAOYSA-N |
LogP | 1.19 |
CAS DataBase Reference | 50-78-2(CAS DataBase Reference) |
NIST Chemistry Reference | Benzoic acid, 2-(acetyloxy)-(50-78-2) |
EPA Substance Registry System | Aspirin (50-78-2) |
Safety Information | |
Hazard Codes | Xn |
Risk Statements | 22-36/37/38 |
Safety Statements | 26-36/37/39 |
OEB | B |
OEL | TWA: 5 mg/m3 |
RIDADR | UN 1851 |
WGK Germany | 1 |
RTECS | VO0700000 |
TSCA | Yes |
HazardClass | 6.1 |
PackingGroup | III |
HS Code | 29182210 |
Hazardous Substances Data | 50-78-2(Hazardous Substances Data) |
Toxicity | LD50 orally in mice, rats: 1.1, 1.5 g/kg (Hart) |
