Thiamine chloride
Critical Role in Carbohydrate Metabolism: Thiamine functions as an essential cofactor in biochemical pathways, facilitating the conversion of carbohydrates into metabolically available energy through its coenzymatic activity.
Maintenance of Neurological Integrity: This micronutrient is crucial for preserving normal neural physiology and preventing the development of neurological pathologies.
Enhancement of Cardiac Performance: Thiamine contributes to the maintenance of optimal myocardial function and supports efficient circulatory dynamics.
Improvement of Digestive Efficiency: It augments gastrointestinal processes by enhancing enzymatic catalysis and improving nutrient assimilation.
Vitamin B1, commonly designated as thiamine or thiamine hydrochloride, constitutes an essential member of the B-vitamin complex. This micronutrient performs critical functions in facilitating carbohydrate metabolism and serves as a fundamental requirement for maintaining normal neurological transmission, cardiac performance, and digestive operations. Through its phosphorylation with adenosine triphosphate, it generates thiamine pyrophosphate (also known as cocarboxylase), which functions as an indispensable coenzyme in carbohydrate metabolic pathways.
Melting point | 248 °C (decomp) |
density | 1.3175 (rough estimate) |
refractive index | 1.5630 (estimate) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | DMSO : 6 mg/mL (19.95 mM) |
form | Solid |
color | White to off-white |
InChI | InChI=1S/C12H17N4OS.ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);1H/q+1;/p-1 |
InChIKey | MYVIATVLJGTBFV-UHFFFAOYSA-M |
SMILES | O([H])CCC1=C(C)[N+](=CS1)CC1C=NC(=NC=1N)C.[Cl-] |
LogP | -3.930 (est) |
CAS DataBase Reference | 59-43-8(CAS DataBase Reference) |
EPA Substance Registry System | Thiamine (59-43-8) |
Safety Information | |
Hazardous Substances Data | 59-43-8(Hazardous Substances Data) |
Deficiency in this coenzyme disrupts normal oxidative metabolism, leading to abnormal accumulation of pyruvate and lactate, consequently impairing cellular energy production. Furthermore, vitamin B1 demonstrates cholinesterase inhibitory activity. During deficiency states, elevated cholinesterase activity accelerates acetylcholine degradation, resulting in compromised neural transmission efficiency and subsequent alterations in gastrointestinal and cardiac function.
